Answer: D. Lung cancer
According to the NCCN, the most common malignancy in patients with HIV infection is lung cancer; their risk is 2 to 5 times higher than that of the general population. The prevalence of smoking is higher in persons living with HIV, which likely contributes to their higher risk of lung cancer. Immunosuppression is another contributing factor. Patients who smoke and are receiving antiretroviral therapy (ART) have a 6 to 13 times higher likelihood of dying of lung cancer than AIDS-related causes. The NCCN recommends that persons with HIV infection should be screened for lung cancer using the same criteria as for the general population.1
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1. Reid E, Suneja G, Ambinder RF, et al. Cancer in People Living With HIV, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2018;16:986-1017. doi: 10.6004/jnccn.2018.0066.
2. Robbins HA, Pfeiffer RM, Shiels MS, et al. Excess cancers among HIV-infected people in the United States. J Natl Cancer Inst. 2015;107(4). pii: dju503. doi: 10.1093/jnci/dju503. Print 2015 Apr